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Treatmentwith YC-1 also down-regulates Mdm2 in hypoxia, and transfection with an Mdm2overexpression vector rescues the effect of YC-1 on HIF1? [ 30]. EEG shows activity when eyes are closed andactivity when eyes are open.

Four functional variants were evaluated – Q192R(rs662) and L55M (rs854560) in PON1; and S311C (rs7493) and A148G (rs12026) in PON2.According to the results PON1 L55M gene polymorphisms were significantly associated withdiabetic retinopathy with no evidence of between-study heterogeneity. Yang Y, Muzny DM, Reid JG, Bainbridge MN, Willis A, Ward PA, Braxton A, Beuten J, XiaF, Niu Z, Hardison M, Person R, Bekheirnia MR, Leduc MS, Kirby A, Pham P, Scull J, WangM, Ding Y, Plon SE, Lupski JR, Beaudet al, Gibbs RA, Eng CM (2013) Clinical whole-exomesequencing for the diagnosis of Mendelian disorders

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Most signs regress in a week,some persist for months. Improved diagnosis of periprosthetic joint infec-tion by multiplex PCR of sonication fluid from removed implants

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